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Article

Correlation between IDH, ATRX, and TERT promoter mutations in glioma.

Brain tumor pathology - 1 Apr 2020

Ohba Shigeo, Kuwahara Kiyonori, Yamada Seiji, Abe Masato, Hirose Yuichi

Abstract excerpt

According to the 2016 World Health Organization (WHO) classification of central nervous system tumors, diffuse astrocytic and oligodendroglial tumors are differentiated by the presence of isocitrate dehydrogenase 1 or 2 (IDH1/2) mutation and the combined loss of the short arm of chromosome 1 and the long arm of chromosome 19 (1p/19q co-deletion). IDH-mutant astrocytoma often has p53 and alpha-thalassemia/mental...

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PMID: 32227259
DOI: 10.1007/s10014-020-00360-4

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