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Article

TERT, a promoter of CNS malignancies

1 Jan 2020

Abstract excerpt

Abstract As cells replicate their DNA during mitosis, telomeres are shortened due to the inherent limitations of the DNA replication process. Maintenance of telomere length is critical for cancer cells to overcome cellular senescence induced by telomere shortening. Telomerase reverse transcriptase (TERT) is the rate-limiting catalytic subunit of telomerase, an RNA-dependent DNA polymerase that lengthens telomeric...

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Identifiers

PMID: 32226942
DOI: 10.1093/noajnl/vdaa025

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