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Article

When the Ends Are Really the Beginnings: Targeting Telomerase for Treatment of GBM.

Current neurology and neuroscience reports - 10 Mar 2018

Bollam Saumya R, Berens Michael E, Dhruv Harshil D

Abstract excerpt

PURPOSE OF REVIEW: High-throughput genomic sequencing has identified alterations in the gene encoding human telomerase reverse transcriptase (TERT) as points of interest for elucidating the oncogenic mechanism of multiple different cancer types, including gliomas. In gliomas, the TERT promoter mutation (TPM) and resultant overexpression of TERT are observed mainly in the most aggressive (primary...

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Identifiers

PMID: 29525892
DOI: 10.1007/s11910-018-0825-7

Genes

TERT

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When the Ends Are Really the Beginnings: Targeting Telomerase for Treatment of GBM.PMID 29525892Read ↗

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Establishment and Validation of the Detection of TERT Promoter Mutations by Human Gliomas U251 Cell Lines.Semantic proximity Read ↗

TERT PROMOTER MUTATIONS OCCUR FREQUENTLY IN GLIOMAS AND A SUBSET OF TUMORS DERIVED FROM CELLS WITH LOW RATES OF SELF-RENEWALSemantic proximity Read ↗

The Place and Prognostic Value of TERT Promoter Mutation in Molecular Classification in Grade II-III Glial Tumors and Primary Glioblastomas.Semantic proximity Read ↗

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