Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system.

doi:10.1007/s00401-013-1195-5

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Article

Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system.

Acta neuropathologica - 1 Dec 2013

Koelsche Christian, Sahm Felix, Capper David, Reuss David, Sturm Dominik, Jones David T W, Kool Marcel, Northcott Paul A, Wiestler Benedikt, Böhmer Katja, Meyer Jochen, Mawrin Christian, Hartmann Christian, Mittelbronn Michel, Platten Michael, Brokinkel Benjamin, Seiz Marcel, Herold-Mende Christel, Unterberg Andreas, Schittenhelm Jens, Weller Michael, Pfister Stefan, Wick Wolfgang, Korshunov Andrey, von Deimling Andreas

Abstract excerpt

Hot spot mutations in the promoter region of telomerase reverse transcriptase (TERT) have recently been described in several human tumor entities. These mutations result in an upregulation of the telomerase complex activity and thus constitute a relevant mechanism for immortalization of tumor cells. Knowledge of the TERT promoter status in tumors is likely to be of interest for molecular classification and as a...

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Identifiers

PMID: 24154961
DOI: 10.1007/s00401-013-1195-5

Genes

TERT
ATRX
IDH1
IDH2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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