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Article

Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q loss.

Acta neuropathologica - 1 Aug 2013

Arita Hideyuki, Narita Yoshitaka, Fukushima Shintaro, Tateishi Kensuke, Matsushita Yuko, Yoshida Akihiko, Miyakita Yasuji, Ohno Makoto, Collins V Peter, Kawahara Nobutaka, Shibui Soichiro, Ichimura Koichi

Abstract excerpt

Telomere lengthening is one of the key events in most cancers, and depends largely on telomerase activation. Telomerase activation is a well-known phenomenon in gliomas; however, its mechanism remains obscure. In this study, we investigated the presence of mutations in the promoter of the telomerase reverse transcriptase (TERT) gene in a series of 546 gliomas. We found a high incidence of mutually exclusive...

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Source

Identifiers

PMID: 23764841
DOI: 10.1007/s00401-013-1141-6

Genes

TERT
EGFR
IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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