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Article

Paradoxical prognostic impact of TERT promoter mutations in gliomas depends on different histological and genetic backgrounds.

CNS neuroscience & therapeutics - 1 Oct 2017

You Hao, Wu Yao, Chang Kai, Shi Xiao, Chen Xin-Da, Yan Wei, Li Rui

Abstract excerpt

AIMS: The purpose of this study was to explore the clinical significance of telomerase reverse transcriptase (TERT) promoter mutations in gliomas. METHODS AND RESULTS: We used DNA sequencing data to analyze 887 gliomas for TERT promoter mutations based on histological and genetic backgrounds. TERT promoter mutations were detected in 39.6% of low-grade gliomas, 40.3% of anaplastic gliomas, 44.7% of primary...

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Brain Neoplasms
Genetic Background
Glioma
Kaplan-Meier Estimate
Neoplasm Recurrence, Local

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Promoter Regions, Genetic

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Open in PubMed Open full text

Identifiers

PMID: 28868656
DOI: 10.1111/cns.12724
PMCID: PMC6492727

Genes

TERT
EGFR
IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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