Article
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal.
Proceedings of the National Academy of Sciences of the United States of America - 9 Apr 2013
Killela Patrick J, Reitman Zachary J, Jiao Yuchen, Bettegowda Chetan, Agrawal Nishant, Diaz Luis A, Friedman Allan H, Friedman Henry, Gallia Gary L, Giovanella Beppino C, Grollman Arthur P, He Tong-Chuan, He Yiping, Hruban Ralph H, Jallo George I, Mandahl Nils, Meeker Alan K, Mertens Fredrik, Netto George J, Rasheed B Ahmed, Riggins Gregory J, Rosenquist Thomas A, Schiffman Mark, Shih Ie-Ming, Theodorescu Dan, Torbenson Michael S, Velculescu Victor E, Wang Tian-Li, Wentzensen Nicolas, Wood Laura D, Zhang Ming, McLendon Roger E, Bigner Darell D, Kinzler Kenneth W, Vogelstein Bert, Papadopoulos Nickolas, Yan Hai
Abstract excerpt
Malignant cells, like all actively growing cells, must maintain their telomeres, but genetic mechanisms responsible for telomere maintenance in tumors have only recently been discovered. In particular, mutations of the telomere binding proteins alpha thalassemia/mental retardation syndrome X-linked (ATRX) or death-domain associated protein (DAXX) have been shown to underlie a telomere maintenance mechanism not...
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