Article

Cost effective sequencing enables longitudinal profiling of clonal hematopoiesis

2022-02-02

Abstract excerpt

<h4>ABSTRACT</h4> Clonal hematopoiesis of indeterminate potential (CHIP), the age-related expansion of mutant hematopoietic stem cells, confers risk for multiple diseases of aging including hematologic cancer and cardiovascular disease. Whole-exome or genome sequencing can detect CHIP, but due to its high cost, most population studies have been cross-sectional, sequencing only a single timepoint. Here we describe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 20a0baa3-1d77-5b40-a938-1b3097523b37
DOI: 10.1101/2022.01.31.22270028

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cost effective sequencing enables longitudinal profiling of clonal hematopoiesisDOI 10.1101/2022.01.31.22270028Read

Longitudinal profiling of clonal hematopoiesis provides insight into clonal dynamicsSemantic proximity Read

Cost-Effective and Scalable Clonal Hematopoiesis Assay Provides Insight into Clonal Dynamics.Semantic proximity Read

Long-term longitudinal analysis of 4,187 participants reveals insights into determinants of clonal hematopoiesis.Semantic proximity Read

Exome sequencing of 628,388 individuals identifies common and rare variant associations with clonal hematopoiesis phenotypesSemantic proximity Read

Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole GenomesSemantic proximity Read

Genomic and phenomic landscape of clonal hematopoiesis in over a million ancestrally diverse participantsSemantic proximity Read

Detection of clonal hematopoiesis of indeterminate potential via genome or exome sequencing profoundly underestimates disease associationsSemantic proximity Read

Clonal hematopoiesis: Molecular and clinical implications.Semantic proximity Read

Defining clonal hematopoiesis of indeterminate potential: evolutionary dynamics and detection under aging and inflammation.Semantic proximity Read

Clonal hematopoiesis of indeterminate potential and cardiovascular disease.Semantic proximity Read

Ultra-sensitive Sequencing Identifies High Prevalence of Clonal Hematopoiesis-Associated Mutations throughout Adult Life.Semantic proximity Read

A practical approach to curate clonal hematopoiesis of indeterminate potential in human genetic data sets.Semantic proximity Read