Article
Ultra-sensitive Sequencing Identifies High Prevalence of Clonal Hematopoiesis-Associated Mutations throughout Adult Life.
American journal of human genetics - 6 Jul 2017
Acuna-Hidalgo Rocio, Sengul Hilal, Steehouwer Marloes, van de Vorst Maartje, Vermeulen Sita H, Kiemeney Lambertus A L M, Veltman Joris A, Gilissen Christian, Hoischen Alexander
Abstract excerpt
Clonal hematopoiesis results from somatic mutations in hematopoietic stem cells, which give an advantage to mutant cells, driving their clonal expansion and potentially leading to leukemia. The acquisition of clonal hematopoiesis-driver mutations (CHDMs) occurs with normal aging and these mutations have been detected in more than 10% of individuals ≥65 years. We aimed to examine the prevalence and characteristics...
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