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Article

The immunoglobulin heavy chain locus: genetic variation, missing data, and implications for human disease.

Genes and immunity - 1 Jul 2012

Watson C T, Breden F

Abstract excerpt

The immunoglobulin (IG) loci consist of repeated and highly homologous sets of genes of different types, variable (V), diversity (D) and junction (J), that rearrange in developing B cells to produce an individual's highly variable repertoire of expressed antibodies, designed to bind to a vast array of pathogens. This repeated structure makes these loci susceptible to a high frequency of insertion and deletion...

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Identifiers

PMID: 22551722
DOI: 10.1038/gene.2012.12

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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