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Article

Stereospecific Resistance to N2-Acyl Tetrahydro-β-carboline Antimalarials Is Mediated by a PfMDR1 Mutation That Confers Collateral Drug Sensitivity.

ACS infectious diseases - 14 Feb 2025

Bremers Emily K, Butler Joshua H, Do Amaral Leticia S, Merino Emilio F, Almolhim Hanan, Zhou Bo, Baptista Rodrigo P, Totrov Maxim, Carlier Paul R, Cassera Maria Belen

Abstract excerpt

Half the world's population is at risk of developing a malaria infection, which is caused by parasites of the genus Plasmodium. Currently, resistance has been identified to all clinically available antimalarials, highlighting an urgent need to develop novel compounds and better understand common mechanisms of resistance. We previously identified a novel tetrahydro-β-carboline compound, PRC1590, which potently...

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Identifiers

PMID: 39808111
DOI: 10.1021/acsinfecdis.4c01001
PMCID: PMC11828674

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