Article

Amodiaquine resistance in Plasmodium berghei is associated with PbCRT His95Pro mutation, loss of chloroquine, artemisinin and primaquine sensitivity, and high transcript levels of key transporters

2018-06-06

Abstract excerpt

<h4>Background: </h4> The human malaria parasite Plasmodium falciparum has evolved drug evasion mechanisms to all available antimalarials. The combination of amodiaquine-artesunate is among the drug of choice for treatment of uncomplicated malaria. In this combination, a short-acting, artesunate is partnered with long-acting, amodiaquine for which resistance may emerge rapidly especially in high transmission sett...

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Literature Corpus work: 333986d5-ffe7-51fe-86ac-7272055c4db7
DOI: 10.12688/wellcomeopenres.11768.2

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Amodiaquine resistance in Plasmodium berghei is associated with PbCRT His95Pro mutation, loss of chloroquine, artemisinin and primaquine sensitivity, and high transcript levels of key transportersDOI 10.12688/wellcomeopenres.11768.2Read

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