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Article

A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants.

PLoS pathogens - 1 Oct 2024

Ferreira Letícia Tiburcio, Cassiano Gustavo Capatti, Alvarez Luis Carlos Salazar, Okombo John, Calit Juliana, Fontinha Diana, Gil-Iturbe Eva, Coyle Rachael, Andrade Carolina Horta, Sunnerhagen Per, Bargieri Daniel Youssef, Prudêncio Miguel, Quick Matthias, Cravo Pedro V, Lee Marcus C S, Fidock David A, Costa Fabio Trindade Maranhão

Abstract excerpt

Artemisinin-based combination therapy (ACT) is the mainstay of effective treatment of Plasmodium falciparum malaria. However, the long-term utility of ACTs is imperiled by widespread partial artemisinin resistance in Southeast Asia and its recent emergence in parts of East Africa. This underscores the need to identify chemotypes with new modes of action (MoAs) to circumvent resistance to ACTs. In this study, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39471233
DOI: 10.1371/journal.ppat.1012627
PMCID: PMC11521309

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