Article

Collateral sensitivity as a strategy to suppress resistance emergence: the challenge of diverse evolutionary pathways

2022-04-07

Abstract excerpt

Drug resistance remains a major obstacle to malaria control and eradication efforts, necessitating the development of novel therapeutic strategies to treat this disease. Drug combinations based on collateral sensitivity, wherein resistance to one drug causes increased sensitivity to the partner drug, have been proposed as an evolutionary strategy to suppress the emergence of resistance in pathogen populations. In...

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Literature Corpus work: 403e5f1b-2b8c-56f8-88ab-863a1d2cb8de
DOI: 10.1101/2022.04.07.486819

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