Article
Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages.
PLoS pathogens - 1 Oct 2022
Okombo John, Mok Sachel, Qahash Tarrick, Yeo Tomas, Bath Jade, Orchard Lindsey M, Owens Edward, Koo Imhoi, Albert Istvan, Llinás Manuel, Fidock David A
Abstract excerpt
The emergence of Plasmodium falciparum parasite resistance to dihydroartemisinin + piperaquine (PPQ) in Southeast Asia threatens plans to increase the global use of this first-line antimalarial combination. High-level PPQ resistance appears to be mediated primarily by novel mutations in the P. falciparum chloroquine resistance transporter (PfCRT), which enhance parasite survival at high PPQ concentrations in...
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