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Article

CNTNAP4 deficiency in dopaminergic neurons initiates parkinsonian phenotypes.

Theranostics - 1 Jan 2020

Zhang Wenlong, Zhou Miaomiao, Lu Weiye, Gong Junwei, Gao Feng, Li Yuanquan, Xu Xuandong, Lin Yuwan, Zhang Xiaokang, Ding Liuyan, Zhang Zhiling, Li Guihua, Chen Xiang, Sun Xiangdong, Zhu Xiaoqin, Xu Pingyi, Zhang Yunlong

Abstract excerpt

Rationale: Contactin-associated protein-like 4 (CNTNAP4) belongs to the neurexin superfamily and has critical functions in neurological development and synaptic function. Loss of CNTNAP4 in interneurons has been linked to autism, schizophrenia, and epilepsy. CNTNAP4 is also highly enriched in dopaminergic (DA) neurons in the substantia nigra (SN), however, few studies have investigated the role of CNTNAP4 in DA...

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Identifiers

PMID: 32194851
DOI: 10.7150/thno.40798
PMCID: PMC7053186

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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