Article

An In Vivo Model of α-Synuclein Spread from Gut to Brain

2025-03-14

Abstract excerpt

<h4>Background</h4> Parkinson’s disease is a progressive neurodegenerative disorder characterized by the presence of pathological aggregation of the protein alpha-synuclein and the loss of dopaminergic neurons in the substantia nigra. There is evidence that misfolding and propagation of alpha-synuclein aggregates through networks of interconnected neurons is responsible for the pathological spread and progressive...

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Literature Corpus work: 8f2412ba-d350-5298-bb4c-b291d9e3d1e5
DOI: 10.1101/2025.03.13.643189

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