Article

A Versatile AAV-TH-SNCA Model to Study Early α-Synuclein Pathology and Intervention

2026-03-24

Abstract excerpt

<h4>ABSTRACT</h4> Adeno-associated viral (AAV)-mediated overexpression of human wildtype α-synuclein (α-syn) in the substantia nigra (SN) is a widely used approach to model Parkinson’s disease (PD) in rodents. However, variability in the ability of AAV-based systems to induce nigrostriatal pathology and motor deficits has limited reproducibility across studies, especially in mice. Here, we systematically optimize...

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Literature Corpus work: 79d8b644-6908-5f4b-9c80-1fce15f0c83c
DOI: 10.64898/2026.03.20.712963

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