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Article

Genomic stability of mouse spermatogonial stem cells in vitro.

Scientific reports - 17 Dec 2021

Chuma Shinichiro, Kanatsu-Shinohara Mito, Katanaya Ami, Hosokawa Mihoko, Shinohara Takashi

Abstract excerpt

Germline mutations underlie genetic diversity and species evolution. Previous studies have assessed the theoretical mutation rates and spectra in germ cells mostly by analyzing genetic markers and reporter genes in populations and pedigrees. This study reported the direct measurement of germline mutations by whole-genome sequencing of cultured spermatogonial stem cells in mice, namely germline stem (GS) cells,...

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Identifiers

PMID: 34921203
DOI: 10.1038/s41598-021-03658-1
PMCID: PMC8683475

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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