Article
Variation in genome-wide mutation rates within and between human families.
Nature genetics - 12 Jun 2011
Conrad Donald F, Keebler Jonathan E M, DePristo Mark A, Lindsay Sarah J, Zhang Yujun, Casals Ferran, Idaghdour Youssef, Hartl Chris L, Torroja Carlos, Garimella Kiran V, Zilversmit Martine, Cartwright Reed, Rouleau Guy A, Daly Mark, Stone Eric A, Hurles Matthew E, Awadalla Philip
Abstract excerpt
J.B.S. Haldane proposed in 1947 that the male germline may be more mutagenic than the female germline. Diverse studies have supported Haldane's contention of a higher average mutation rate in the male germline in a variety of mammals, including humans. Here we present, to our knowledge, the first direct comparative analysis of male and female germline mutation rates from the complete genome sequences of two...
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