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Article

Modest increase in the de novo single-nucleotide mutation rate in house mice born by assisted reproduction.

Genome research - 5 Jan 2026

Blanco-Berdugo Laura, Garretson Alexis, Dumont Beth L

Abstract excerpt

Approximately 2.6% of live births in the United States are conceived using assisted reproductive technologies (ARTs). Although some ARTs, including in vitro fertilization (IVF) and intracytoplasmic sperm injection, are known to alter the epigenetic landscape of early embryonic development, their impact on DNA sequence stability is unclear. Here, we leverage the strengths of the laboratory mouse model system to...

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Share to Fertilization in Vitro
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Share to Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

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Share to Polymorphism, Single Nucleotide

Share to Reproductive Techniques, Assisted

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Identifiers

PMID: 41233158
DOI: 10.1101/gr.281180.125
PMCID: PMC12758394

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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