Article

Mutation rates and the evolution of germline structure

2015-12-13

Abstract excerpt

Genome sequencing studies of de novo mutations in humans have revealed surprising incongruities with our understanding of human germline mutation. In particular, the mutation rate observed in modern humans is substantially lower than that estimated from calibration against the fossil record, and the paternal age effect in mutations transmitted to offspring is much weaker than expected from our longstanding model...

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Identifiers and source

Literature Corpus work: 30bfcc77-97ef-5e9b-bcb1-fd1ff8dc3b62
DOI: 10.1101/034298

Open publication

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