Article

Pseudouridine-free Ribosome Exhibits Distinct Inter-subunit Movements

2021-06-02

Abstract excerpt

Pseudouridine, the most abundant form of RNA modification, is known to play important roles in ribosome function. Mutations in human DKC1, the pseudouridine synthase responsible for catalyzing the ribosome RNA modification, cause translation deficiencies and are associated with a complex cancer predisposition. The structural basis for how pseudouridine impacts ribosome function remains uncharacterized. Here we rep...

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Literature Corpus work: 1fdbfb1a-c3cc-570f-a4d6-e600b55b2bc1
DOI: 10.1101/2021.06.02.446812

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