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Tuning the ribosome: The influence of rRNA modification on eukaryotic ribosome biogenesis and function

2 Dec 2016

Abstract excerpt

rRNAs are extensively modified during their transcription and subsequent maturation in the nucleolus, nucleus and cytoplasm. RNA modifications, which are installed either by snoRNA-guided or by stand-alone enzymes, generally stabilize the structure of the ribosome. However, they also cluster at functionally important sites of the ribosome, such as the peptidyltransferase center and the decoding site, where they...

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PMID: 27911188
DOI: 10.1080/15476286.2016.1259781

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