Article
rRNA pseudouridylation defects affect ribosomal ligand binding and translational fidelity from yeast to human cells.
Molecular cell - 18 Nov 2011
Jack Karen, Bellodi Cristian, Landry Dori M, Niederer Rachel O, Meskauskas Arturas, Musalgaonkar Sharmishtha, Kopmar Noam, Krasnykh Olya, Dean Alison M, Thompson Sunnie R, Ruggero Davide, Dinman Jonathan D
Abstract excerpt
How pseudouridylation (Ψ), the most common and evolutionarily conserved modification of rRNA, regulates ribosome activity is poorly understood. Medically, Ψ is important because the rRNA Ψ synthase, DKC1, is mutated in X-linked dyskeratosis congenita (X-DC) and Hoyeraal-Hreidarsson (HH) syndrome. Here, we characterize ribosomes isolated from a yeast strain in which Cbf5p, the yeast homolog of DKC1, is...
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