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A single-cell framework identifies functionally and molecularly distinct multipotent progenitors in adult human hematopoiesis

1 Sept 2025

Abstract excerpt

Hematopoietic multipotent progenitors (MPPs) regulate blood cell production to meet the evolving demands of an organism. Adult human MPPs remain ill defined, whereas mouse MPPs are well characterized, with distinct immunophenotypes and lineage potencies. Using multi-omic single-cell analyses and functional assays, we identified distinct human MPPs within Lin-CD34+CD38dim/lo adult bone marrow with unique...

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PMID: 40911415
DOI: 10.1016/j.celrep.2025.116236

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