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Single cell analyses identify a highly regenerative and homogenous human CD34+ hematopoietic stem cell population

19 Apr 2022

Abstract excerpt

Abstract The heterogeneous nature of human CD34+ hematopoietic stem cells (HSCs) has hampered our understanding of the cellular and molecular trajectories that HSCs navigate during lineage commitment. Using various platforms including single cell RNA-sequencing and extensive xenotransplantation, we have uncovered an uncharacterized human CD34+ HSC population. These CD34+EPCR+(CD38/CD45RA)− (simply as EPCR+) HSCs...

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PMID: 35440586
DOI: 10.1038/s41467-022-29675-w

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