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The global clonal complexity of the murine blood system declines throughout life and after serial transplantation

20 Feb 2019

Abstract excerpt

Abstract Although many recent studies describe the emergence and prevalence of “clonal hematopoiesis of indeterminate potential” in aged human populations, a systematic analysis of the numbers of clones supporting steady-state hematopoiesis throughout mammalian life is lacking. Previous efforts relied on transplantation of “barcoded” hematopoietic stem cells (HSCs) to track the contribution of HSC clones to...

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PMID: 30782612
DOI: 10.1182/blood-2018-09-873059

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