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Article

Aging diminishes thymic output, reduces naive T cells, promotes memory T-cell accumulation, and impairs thymic regeneration.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Jun 2026

Konovalova Daria M, Cooper Madison D, Huang Shuli, Shane Danielle X, Mulhern Jordyn S, Chiao Ying Ann, Yuan Sarah Y, Ma Yonggang

Abstract excerpt

Aging increases susceptibility to a wide range of diseases, partially due to alterations in T lymphocytes. This study aimed to characterize age-related changes in T-cell output, phenotype, and function under basal conditions and after myocardial infarction (MI). Compared with young mice (2-6 mo), aged mice (≥18 mo) demonstrated reduced thymic size and fewer developing thymocytes. Accordingly, circulating T-cell...

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PMID: 42030224
DOI: 10.1152/ajpregu.00242.2025
PMCID: PMC13225476

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