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Article

Association between Immunosenescence, Mitochondrial Dysfunction and Frailty Syndrome in Older Adults

22 Dec 2022

Abstract excerpt

Aging is associated with changes in the immune system, increased inflammation and mitochondrial dysfunction. The relationship between these phenomena and the clinical phenotype of frailty is unclear. Here, we evaluated the immune phenotypes, T cell functions and mitochondrial functions of immune cells in frail and robust older subjects. We enrolled 20 frail subjects age- and gender-matched with 20 robust...

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PMID: 36611837
DOI: 10.3390/cells12010044

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