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Article

Does metabolic reprogramming underpin age-associated changes in T cell phenotype and function?

Free radical biology & medicine - 1 Jun 2014

Torrão Rita C, Bennett Stuart J, Brown James E, Griffiths Helen R

Abstract excerpt

T cells are required for an effective adaptive immune response. The principal function of T cells is to promote efficient removal of foreign material by identifying and mounting a specific response to nonself. A decline in T cell function in aging is thought to contribute to reduced response to infection and vaccination and an increase in autoimmunity. This may in part be due to the age-related decrease in naïve...

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Identifiers

PMID: 24632379
DOI: 10.1016/j.freeradbiomed.2014.03.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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