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Epitope convergence of broadly HIV-1 neutralizing IgA and IgG antibody lineages in a viremic controller

1 Mar 2022

Abstract excerpt

Decrypting the B cell ontogeny of HIV-1 broadly neutralizing antibodies (bNAbs) is paramount for vaccine design. Here, we characterized IgA and IgG bNAbs of three distinct B cell lineages in a viremic controller, two of which comprised only IgG+ or IgA+ blood memory B cells; the third combined both IgG and IgA clonal variants. 7-269 bNAb in the IgA-only lineage displayed the highest neutralizing capacity despite...

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PMID: 35230385
DOI: 10.1084/jem.20212045

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