Article

HIV-1 CD4-binding site germline antibody–Env structures inform vaccine design

2022-03-26

Abstract excerpt

BG24, a VRC01-class broadly neutralizing antibody (bNAb) against HIV-1 Env with relatively few somatic hypermutations (SHMs), represents a promising target for vaccine strategies to elicit CD4-binding site (CD4bs) bNAbs. To understand how SHMs correlate with BG24 neutralization of HIV-1, we solved 4.1 Å and 3.4 Å single-particle cryo-EM structures of two inferred germline (iGL) BG24 precursors complexed with engin...

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Literature Corpus work: 36efb428-06e4-5fb0-9f9e-e66cd91c540a
DOI: 10.1101/2022.03.25.485873

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