Article

Dependence on a variable residue limits the breadth of an HIV MPER neutralizing antibody, despite convergent evolution with broadly neutralizing antibodies

2022-03-19

Abstract excerpt

<h4>ABSTRACT</h4> Broadly neutralizing antibodies (bNAbs) that target the membrane-proximal external region (MPER) of HIV gp41 envelope, such as 4E10 and VRC42.01, can neutralize >95% of viruses. These two MPER-directed monoclonal antibodies share germline antibody genes ( IGHV1-69 and IGKV3-20) and form a bNAb epitope class. Furthermore, convergent evolution within these two lineages towards a 111.2 GW 111.3...

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Literature Corpus work: 39c42db1-255b-5801-b279-416327b22fa3
DOI: 10.1101/2022.03.18.484856

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