Article

Cognitive pleiotropy reveals disorder-specific and shared biology for schizophrenia and bipolar disorder

2026-07-10

Abstract excerpt

Schizophrenia (SCZ) and bipolar disorder (BIP) share substantial common-variant liability but differ in clinical course, cognition, and treatment response. We previously resolved this overlap into three cognitively divergent components, SCZcondBIP (negatively correlated with cognition and education), BIPcondSCZ (positively correlated with both), and PSY-shared (negative with cognition, positive with education), re...

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Literature Corpus work: 1fa37912-e207-5c56-8099-e83751d4c0ec
DOI: 10.64898/2026.07.07.26357446

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