Article
Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate.
PLoS genetics - 1 Apr 2013
Andreassen Ole A, Thompson Wesley K, Schork Andrew J, Ripke Stephan, Mattingsdal Morten, Kelsoe John R, Kendler Kenneth S, O'Donovan Michael C, Rujescu Dan, Werge Thomas, Sklar Pamela, Roddey J Cooper, Chen Chi-Hua, McEvoy Linda, Desikan Rahul S, Djurovic Srdjan, Dale Anders M
Abstract excerpt
Several lines of evidence suggest that genome-wide association studies (GWAS) have the potential to explain more of the "missing heritability" of common complex phenotypes. However, reliable methods to identify a larger proportion of single nucleotide polymorphisms (SNPs) that impact disease risk are currently lacking. Here, we use a genetic pleiotropy-informed conditional false discovery rate (FDR) method on...
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