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A genome-wide search for pleiotropy in more than 100,000 harmonized longitudinal cognitive domain scores

22 Jun 2023

Abstract excerpt

Abstract Background More than 75 common variant loci account for only a portion of the heritability for Alzheimer’s disease (AD). A more complete understanding of the genetic basis of AD can be deduced by exploring associations with AD-related endophenotypes. Methods We conducted genome-wide scans for cognitive domain performance using harmonized and co-calibrated scores derived by confirmatory factor analyses...

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PMID: 37349795
DOI: 10.1186/s13024-023-00633-4

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