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Article

The shared genetic architecture of schizophrenia, bipolar disorder and lifespan.

Human genetics - 1 Mar 2021

Muntané Gerard, Farré Xavier, Bosch Elena, Martorell Lourdes, Navarro Arcadi, Vilella Elisabet

Abstract excerpt

Psychiatric disorders such as Schizophrenia (SCZ) and Bipolar Disorder (BD) represent an evolutionary paradox, as they exhibit strong negative effects on fitness, such as decreased fecundity and early mortality, yet they persist at a worldwide prevalence of approximately 1%. Molecular mechanisms affecting lifespan, which may be widely common among complex diseases with fitness effects, can be studied by the...

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PMID: 32772156
DOI: 10.1007/s00439-020-02213-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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