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Article

Splitting schizophrenia: divergent cognitive and educational outcomes revealed by genomic structural equation modelling.

Molecular psychiatry - 1 Jun 2026

Watson Cameron James, Zvrskovec Johan, Merola Giuseppe Pierpaolo, Gilchrist Lachlan, Haussler Senta M, Schattner Miryam, Lo Chris Wai Hang, Breen Gerome, Murray Robin M, Lewis Cathryn Μ, Vassos Evangelos

Abstract excerpt

The genetic relationship between schizophrenia, IQ, and educational attainment (EA) is complex. Schizophrenia polygenic scores (PGS) are linked to lower IQ, whilst higher IQ-PGS correlates with reduced schizophrenia risk. Paradoxically, genetic predisposition to higher EA has been associated with increased schizophrenia risk, a relationship potentially confounded by genetic overlap between schizophrenia and...

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PMID: 41620580
DOI: 10.1038/s41380-026-03444-3
PMCID: PMC13190233

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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