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Article

Microglia contribute to neuronal synchrony despite endogenous ATP-related phenotypic transformation in acute mouse brain slices.

Nature communications - 26 Jun 2024

Berki Péter, Cserép Csaba, Környei Zsuzsanna, Pósfai Balázs, Szabadits Eszter, Domonkos Andor, Kellermayer Anna, Nyerges Miklós, Wei Xiaofei, Mody Istvan, Kunihiko Araki, Beck Heinz, Kaikai He, Ya Wang, Lénárt Nikolett, Wu Zhaofa, Jing Miao, Li Yulong, Gulyás Attila I, Dénes Ádám

Abstract excerpt

Acute brain slices represent a workhorse model for studying the central nervous system (CNS) from nanoscale events to complex circuits. While slice preparation inherently involves tissue damage, it is unclear how microglia, the main immune cells and damage sensors of the CNS react to this injury and shape neuronal activity ex vivo. To this end, we investigated microglial phenotypes and contribution to network...

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Identifiers

PMID: 38926390
DOI: 10.1038/s41467-024-49773-1
PMCID: PMC11208608

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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