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Article

Microglia in the aged brain develop a hypoactive molecular phenotype after surgery.

Journal of neuroinflammation - 18 Dec 2024

Yin Zhuoran, Leonard Anna K, Porto Carl M, Xie Zhongcong, Silveira Sebastian, Culley Deborah J, Butovsky Oleg, Crosby Gregory

Abstract excerpt

BACKGROUND: Microglia, the resident immune cells of the brain, play a crucial role in maintaining homeostasis in the central nervous system (CNS). However, they can also contribute to neurodegeneration through their pro-inflammatory properties and phagocytic functions. Acute post-operative cognitive deficits have been associated with inflammation, and microglia have been implicated primarily based on...

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Aging
Brain
Cytokines
CCL2 gene
Mice
Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39696348
DOI: 10.1186/s12974-024-03307-0
PMCID: PMC11658347

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CCL2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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