Article

Development of super-specific epigenome editing by targeted allele-specific DNA methylation

2023-07-11

Abstract excerpt

<h4>Background: </h4> Epigenome editing refers to the targeted reprogramming of genomic loci using an EpiEditor which may consist of dCas9, DNMT3A/3L and sgRNA. Methylation of the locus can lead to a modulation of gene expression. Allele-specific DNA methylation (ASM) refers to the targeted methylation delivery only to one allele of a locus. In the context of diseases caused by a dominant mutation, the selective D...

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Literature Corpus work: 6ccda58b-4d5f-586a-883d-ab2e44f407cf
DOI: 10.21203/rs.3.rs-3143155/v1

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