Article

Clonal expansion of mitochondrial DNA deletions is a private mechanism of ageing in long-lived animals

2018-02-28

Abstract excerpt

<h4>Summary</h4> Disruption of mitochondrial metabolism and loss of mitochondrial DNA (mtDNA) integrity are widely considered as evolutionarily conserved (public) mechanisms of ageing (López-Otín et al. 2013). Human ageing is associated with loss in skeletal muscle mass and function (Sarcopenia), contributing significantly to morbidity and mortality. Muscle ageing is associated with loss of mtDNA integrity. In h...

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Literature Corpus work: 1f0d3940-0a20-52d9-953c-7aa993ffccd4
DOI: 10.1101/273326

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