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Mitochondrial changes in ageing Caenorhabditis elegans--what do we learn from superoxide dismutase knockouts?

PloS one - 1 Jan 2011

Gruber Jan, Ng Li Fang, Fong Sheng, Wong Yee Ting, Koh Soon Ann, Chen Ce-Belle, Shui Guanghou, Cheong Wei Fun, Schaffer Sebastian, Wenk Markus R, Halliwell Barry

Abstract excerpt

One of the most popular damage accumulation theories of ageing is the mitochondrial free radical theory of ageing (mFRTA). The mFRTA proposes that ageing is due to the accumulation of unrepaired oxidative damage, in particular damage to mitochondrial DNA (mtDNA). Within the mFRTA, the "vicious cycle" theory further proposes that reactive oxygen species (ROS) promote mtDNA mutations, which then lead to a further...

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PMID: 21611128
DOI: 10.1371/journal.pone.0019444
PMCID: PMC3097207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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