Article

Multi-tissue landscape of somatic mtDNA mutations indicates tissue specific accumulation and removal in aging

2022-09-01

Abstract excerpt

<h4>ABSTRACT</h4> Accumulation of somatic mutations in the mitochondrial genome (mtDNA) during aging has long been proposed as a possible mechanism of mitochondrial and tissue dysfunction. A thorough characterization of age-associated mtDNA somatic mutations has been hampered by the limited ability to detect low frequency mutations. Here, we used Duplex Sequencing on eight tissues of an aged mouse cohort to detec...

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Literature Corpus work: f1df97e2-b029-53fe-b24d-29a79e887a9c
DOI: 10.1101/2022.08.30.505884

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