Article
Mitochondrial DNA mutations as a fundamental mechanism in physiological declines associated with aging.
Aging cell - 1 Feb 2003
Pak Jeong W, Herbst Allen, Bua Entela, Gokey Nolan, McKenzie Debbie, Aiken Judd M
Abstract excerpt
The hypothesis that mitochondrial DNA damage accumulates and contributes to aging was proposed decades ago. Only recently have technological advancements, which facilitate microanalysis of single cells or portions of cells, revealed that mtDNA deletion mutations and, perhaps, single nucleotide mutations accumulate to physiologically relevant levels in the tissues of various species with age. Although a link...
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