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Article

Cardiometabolic heart failure with preserved ejection fraction: from molecular signatures to personalized treatment.

Cardiovascular diabetology - 3 Jul 2025

Gorica Era, Geiger Martin A, Di Venanzio Ludovica, Atzemian Natalia, Kleeberger Jan Alphard, Grigorian Dominique, Mongelli Alessia, Emini Veseli Besa, Mohammed Shafeeq A, Ruschitzka Frank, Flammer Andreas J, Niederseer David, Costantino Sarah, Paneni Francesco

Abstract excerpt

Heart failure with preserved ejection fraction (HFpEF) represents nearly half of all heart failure cases globally. The increased prevalence of cardiometabolic disease, driven by unhealthy lifestyles, has led to a growing population of people developing the so called "cardiometabolic HFpEF (cmHFpEF)" phenotype. This condition represents an end stage cardiometabolic phenotype which results from the clustering of...

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PMID: 40611109
DOI: 10.1186/s12933-025-02774-w
PMCID: PMC12225509

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