Article

Salt-inducible kinase inhibition promotes weight loss and improves the diastolic function of obesity-related heart failure with preserved ejection fraction in mice

2025-03-10

Abstract excerpt

<h4>Background</h4> Obesity negatively impacts cardiac function and is closely associated with heart failure with preserved ejection fraction (HFpEF). Salt-inducible kinases (SIKs) are critical regulators of energy metabolism and cardiovascular function. Small molecule SIK inhibitors have been developed but their effect in treating obesity-related HFpEF remains unexplored. We recently discovered that pharmacologi...

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Literature Corpus work: dd381e6f-8b31-59f7-9049-936bb6d3f75e
DOI: 10.1101/2025.03.02.640935

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