Article

Sodium-glucose co-transporter 2 Inhibitors Act Independently of <i>SGLT2</i> to Confer Benefit for Heart Failure with Reduced Ejection Fraction in Mice

2024-05-02

Abstract excerpt

Sodium-glucose co-transporter 2 inhibitors (SGLT2i) are novel, potent heart failure medications with an unknown mechanism of action. We sought to determine if the beneficial actions of SGLT2i in heart failure were on- or off-target, and related to metabolic reprogramming, including increased lipolysis and ketogenesis. The phenotype of mice treated with empagliflozin and genetically engineered mice constitutively l...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 149def66-e0e0-591a-a5fb-a6d1f3d4bf45
DOI: 10.1101/2024.04.29.591665

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sodium-glucose co-transporter 2 Inhibitors Act Independently of <i>SGLT2</i> to Confer Benefit for Heart Failure with Reduced Ejection Fraction in MiceDOI 10.1101/2024.04.29.591665Read

Harnessing the Synergy of SGLT2 Inhibitors and Continuous Ketone Monitoring (CKM) in Managing Heart Failure Among Patients with Type 1 DiabetesSemantic proximity Read

Hepatic Ketogenesis Attenuates Cardiac Hypertrophy via Metabolic ReprogrammingSemantic proximity Read

SGLT2 Inhibitors Produce Cardiorenal Benefits by Promoting Adaptive Cellular Reprogramming to Induce a State of Fasting Mimicry: A Paradigm Shift in Understanding Their Mechanism of ActionSemantic proximity Read

Targeting Metabolic Dysfunction and Inflammation with Sotagliflozin Reverses Diastolic Dysfunction in Experimental HFpEFSemantic proximity Read

Salt-inducible kinase inhibition promotes weight loss and improves the diastolic function of obesity-related heart failure with preserved ejection fraction in miceSemantic proximity Read

SGLT2 transcriptomic expression atlas supports a kidney-centric role for empagliflozin’s benefits in heart failureSemantic proximity Read

The impact of dapagliflozin for the myocardial metabolomic profiles of mice with chronic heart failure induced by a high fat dietSemantic proximity Read

Kidney single-cell transcriptomes uncover SGLT2i-induced metabolic reprogramming via restoring glycolysis and fatty acid oxidationSemantic proximity Read

Metabolic inflexibility across heart failure phenotypes: mechanisms and type-specific therapeutic implications.Semantic proximity Read

Obesity and diabetes related disturbances in systemic metabolism induce a cardiometabolic heart failure with preserved ejection fraction phenotype in a combined high-fat, high sucrose diet and streptozotocin mouse modelSemantic proximity Read

Empagliflozin induces the transcriptional program for nutrient homeostasis in skeletal muscle in normal miceSemantic proximity Read

Loss of cardiac PFKFB2 drives Metabolic, Functional, and Electrophysiological Remodeling in the HeartSemantic proximity Read