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Individual intestinal symbionts induce a distinct population of RORγ <sup>+</sup> regulatory T cells

13 Aug 2015

Abstract excerpt

T regulatory cells that express the transcription factor Foxp3 (Foxp3(+) T(regs)) promote tissue homeostasis in several settings. We now report that symbiotic members of the human gut microbiota induce a distinct T(reg) population in the mouse colon, which constrains immuno-inflammatory responses. This induction—which we find to map to a broad, but specific, array of individual bacterial species—requires the...

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PMID: 26272906
DOI: 10.1126/science.aaa9420

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